The trick to nixos, in this instance, is to use a python venv. Python dependencies are fickle and nasty in the first place, triply so when talking about fast-churning AI code, I tried specifying everything with nix, I succeeded, and then you have random comfyui plugins assuming they can get a writeable location by constructing a path from comfyui’s main.py. It’s not worth it: Let python be the only dependency you feed in, let pip and general python jank do the rest.